Abstract | The seismic fragility is assessed for typical high-rise stacks encountered in oil refineries, namely process towers, chimneys, and flares. Models of varying complexity were developed for the structures of interest, attempting to balance computational complexity and accuracy regarding the structural dynamic and strength properties. The models were utilized along with a set of hazard-consistent ground motions for evaluating the seismic demands through incremental dynamic analysis. Demand/capacity-related uncertainties were explicitly accounted for in the proposed framework. Damage states were defined for each of the examined structure considering characteristic serviceability and ultimate limit states. Τhe proposed resource-efficient roadmap for the analytical seismic fragility assessment of typical high-rise stacks, as well as the findings of the presented research work are available to be exploited in seismic risk assessment studies of oil refineries.