Abstract | Blast-loaded structures are presently assessed and designed following a deterministic approach, where only a set of structural analyses under worst-case design scenarios are carried out in order to verify each limit state. As a rational alternative, a conditional probabilistic approach is introduced to offer comprehensive risk assessment and to allow the design with user-defined confidence in meeting performance targets in view of uncertainties. To simplify the probabilistic consideration of the uncertain parameters, the determination of the blast hazard and the structural response are decoupled into the evaluation of blast hazard curves and structural fragilities curves, respectively, by introducing a single conditioning intensity measure. This is chosen to be the impulse density, shown to be sufficient for impulse-governed scenarios, achieving a reduction of the computational effort by several orders of magnitude without introducing bias. Furthermore a problem-specific safety factor formulation is introduced to incorporate the influence of uncertainties in a simple manner, akin to current engineering practice. As a proof-of-concept test, a steel built-up blast resistant door is subjected to an accidental detonation of mortar rounds in a military facility. The equivalent single degree of freedom model is adopted in order to conduct the structural analyses, while detailed finite element analyses are carried out for validation. Finally, the conditional approach risk analysis on the steel door is compared against the results obtained through the comprehensive (probabilistic) unconditional approach, showing the validity of both the proposed intensity measure and safety factor formulation.