Abstract | Ensuring the structural and operational integrity of oil refineries in case of an earthquake event is of utmost importance for the society, the environment, and the economy. A potential failure in such critical facilities may trigger a number of undesirable situations, such as fire, injuries, environmental pollution, etc. Hence, improving safety plan and increasing seismic resilience is a necessity that requires the development of reliable models and seismic risk assessment tools. Towards this direction, this paper presents a seismic fragility study of two characteristic steel high-rise stacks encountered in oil refineries, namely a relatively low-rise chimney and a process tower. The developed of reduced-order numerical models, the selection of appropriate engineering demand parameters to capture the seismic response of the structures, the calculation of the fragility curves, and finally the evaluation of the overall seismic response are presented. The results could be exploited in the context of a seismic risk assessment study of an oil refinery, as an integrated system.