Abstract | The Eurocode 8—Part 4 approaches, per their December 2022 update, are presented for the design of acceleration-sensitive industrial ancillary components. The seismic performance of such nested and/or supported ancillary elements, namely mechanical and electrical equipment, machinery, vessels, etc. is critical for the safety and operability of an industrial facility in the aftermath of an earthquake. Of primary importance are the structural characteristics of the supporting structure and the supported component, pertaining to resonance, strength, and ductility, and whether these are known (and to what degree) during initial design and/or subsequent modifications and upgrades. Depending on the availability and reliability of information on the overall system, the Eurocode methods comprise (a) a detailed component/structure-specific design accounting for all pertinent component and building characteristics, equivalent to typical building design per Eurocode 8—Part 1–2, (b) a conservative approach where a blanket safety factor is applied when little or no such data is available, and (c) a ductile design founded on the novel concept of inserting a fuse of verified ductility and strength in the load path between the supporting structure and the ancillary element. All three methods are evaluated and compared on the basis of a case-study industrial structure, showing how an engineer can achieve economy without compromising safety under different levels of uncertainty.