Abstract | Open-frame reinforced concrete (RC) buildings for supporting essential mechanical/electrical equipment are encountered in almost all industrial plants. Hence, to ensure the undisrupted operation of an industrial facility, the integrity of such structural assets along with their nested nonstructural components should be verified against a spectrum of natural and man-made hazards. Focusing on the earthquake peril, this study presents an analytical seismic fragility assessment framework for two RC equipment-supporting buildings that are deemed typical to an oil refinery. The proposed fully-probabilistic fragility concept, utilises reduced-order building models for the evaluation of the induced seismic demands and accounts for both drift and acceleration-sensitive failure modes in the definition of the damage states. The findings can be exploited by designers and facility managers for developing efficient pre- and post-event risk-aware mitigation/response strategies and are delivered in a manner that can be readily integrated into the seismic performance assessment framework of an entire industrial facility.