Abstract | Risk and resilience are assessed for the Metsovo-Panagia segment of the Egnatia highway in Greece, focusing on the seismic and the wind hazard. This segment comprises steep slopes, bridges and the operator control building that are vulnerable to the seismic hazard as well as an ensemble of sign-support structures over several kilometers of the highway that are exposed to environmental conditions, thus being susceptive to fatigue damage under wind loading. The aim is to develop a tool for pre-event risk assessment and rapid post-event inspection of critical road infrastructure by combining hazard, vulnerability, and sensor information to predict the resulting consequences. A component-based approach is adopted for the critical highway assets while asset interdependencies are considered to assess the system-level consequences for the entire highway. These are quantified in terms of direct monetary losses and downtime as well as actions that the road operator shall take until repair actions have finished, i.e., number of closed lanes and the allowable speed limit in the remaining open ones. This allows tracing back the consequences after an event to individual components/assets and can help road operators establish inspection prioritization protocols and manage associated incidents, facilitating the rapid assessment of the state of the highway and optimal recovery to full functionality.