Abstract | Crude oil refineries are high-importance infrastructure that play a key role in the energy supply chain. Securing the operational and structural integrity of refineries in the aftermath of an earthquake is crucial for avoiding the undesirable consequences of a Natural-Technological (NaTech) incident, such as injuries, environmental pollution, business interruption, and monetary losses. Refineries are designed, constructed, maintained, and operated under a strict framework of standards and regulations. Still, seismic-related NaTech incidents are occurring. Thus, to assess with more confidence and consequently improve, if needed, their seismic resilience, a coherent performance-based framework needs to be utilised, that accounts for the refinery as an integrated system comprising a variety of structural typologies, such as buildings, tanks, and high-rise stacks. These structures have very diverse dynamic properties and hence seismic responses. Towards this objective, a virtual crude oil refinery is examined herein as a case study. The aim is to showcase the steps of a seismic risk assessment framework when applied to such infrastructures, focusing on the evaluation of the seismic hazard, the development of the exposure model, the numerical analysis of the structures, and the preliminary damage assessment of the facility using different earthquake scenarios.