Abstract | A seismic fragility assessment methodology is presented for equipment-supporting reinforced concrete and steel buildings that are typically encountered in oil refineries. Using a suite of hazard-consistent ground motions and reduced-order models, incremental dynamic analysis is performed to obtain the seismic demand of the structural systems examined. Appropriate drift- and floor acceleration-sensitive failure modes are considered to define the limit state capacities of the supporting structure and the nested non-structural process equipment. Special care is exercised on the demand and capacity representation of structural and non-structural components, offering a transparent roadmap for undertaking analytical fragility assessment for equipment-supporting buildings typical to an oil refinery. The findings and the proposed methodology can be exploited by designers and facility managers for mitigating the risk of failure prior to the occurrence of an earthquake event, for designing the pertinent structures and their non-structural components by means of a risk-aware performance-based methodology, or as feed data in early warning systems.