Summary | Offshore wind turbines constitute a modern solution for the production of energy using wind power. However, they are subject to uncertain loads due to the combination of dynamic parameters, such as wind and waves. For this reason, the valid assessment and appropriate design against those parameters are real challenges for the engineers. The purpose of this paper is to present a methodology for the analysis of a standard offshore wind turbine sited at a specific area in the Aegean Sea. In specific, the loads due to the combination of wind and waves are calculated by statistically processing anemological and wave data of the area using appropriate software. Finally, the calculated loads are used in order to specify the annual fatigue damage and the predicted fatigue life of the structure.