TwinCity aims to leverage existing tools and services (e.g., climate models, modelling of extreme events and their impacts, EU services, etc.), and develop novel technologies (Layered-Block Models, City Digital Twins) to deliver an integrated socioeconomic resilience assessment platform, addressing multi-hazard risk understanding, better preparedness, faster, adapted and efficient response, and sustainable reconstruction of urban areas. Taking advantage of the unique opportunity offered by the COVID-19 quarantine to calibrate for the effect of business shutdown and recovery, TwinCity offers a robust digital twin of an urban area that accounts for local socioeconomic and business ecosystems to run end-to-end simulations of multiple “what-if” disruption scenarios. The final goal is to offer an open-source basis upon which performance, risk and resilience can be assessed by stake-holders, to be tested with a large-scale pilot study of an island Greek town subject to earthquake and weather/climate hazards.